Oxidized tyrosine products OTPs have been detected in commercial foods with high protein content. Dityrosine Dityr is a typical oxidized tyrosine product. The previous studies in our lab demonstrated that dityrosine administration impaired glucose tolerance and suppressed the bio-function of thyroid hormone T3 of mice. Therefore, the present study investigates the potential impact of dietary OTPs on the pancreatic function. The blood glucose, plasma insulin levels, and plasma free thyroid hormones THs were then measured.
Scientometric analysis of mTOR signaling pathway in liver disease
teresa gonzalez - e-karkonosze.info
Print Bookmark Share. Insulin resistance and glucose intolerance are a hallmark of Type II diabetes, and have been closely associated with obesity. Recent work also demonstrates how the mTORC2 complex is negatively regulated by triacylglycerol TAG synthesis, impairing insulin signaling and suggesting a mechanism for acquisition of insulin resistance in the liver, and breaks down the effects of chronic rapamycin treatment on longevity and insulin resistance by disruption mTORC1 and mTORC2, respectively. Back to top Introduction Insulin activity plays an important role in glucose and lipid metabolism, and insulin resistance in muscle, liver, and adipose tissue is a significant threat to public health. This condition is thought to result from several physiological mechanisms, including but not limited to inflammation, ectopic lipid accumulation in insulin-responsive tissues, and the unfolded protein response 1. Each complex plays a distinct role in regulating insulin sensitivity: mTORC1 inhibits insulin signaling via its substrate S6K1, whereas mTORC2 has been shown to have a positive effect on glucose uptake and tolerance 4. However, insulin sensitivity improved in AKO muscle, liver, and adipose tissue.
Target of rapamycin (TOR) signaling (Homo sapiens)
Insulin resistance is the common denominator of several diseases including type 2 diabetes and cancer, and investigating the mechanisms responsible for insulin signaling impairment is of primary importance. A mathematical model of the insulin signaling network ISN is proposed and used to investigate the dose-response curves of components of this network. Experimental data of C2C12 myoblasts with phosphatase and tensin homologue PTEN suppressed and data of L6 myotubes with induced insulin resistance have been analyzed by the model.
Metrics details. Numerous PI3K inhibitors have exhibited good results in preclinical studies, and some have been clinically tested in haematologic malignancies and solid tumours. We aimed to provide useful suggestions for additional research on the mechanism underlying the biological regulation of this pathway. Multicellular organisms comprise an orderly and controllable collection of cells.